Sunday, March 24, 2013

Senate's first budget in four years: A chip off partisan gridlock?

Billions in new spending and a $1 trillion tax hike for the wealthy are mainstays of the first Senate budget in four years. It's the polar opposite of the Republican House?budget passed this week.

By Patrik Jonsson,?Staff writer / March 23, 2013

Sen. Mary Landrieu, D-La. rushes with other lawmakers to the Senate floor on Capitol Hill in Washington Friday to vote on amendments to the budget resolution.

J. Scott Applewhite/AP

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In what Sen. Majority Leader Harry Reid called a "Herculean feat," the US Senate passed its first budget in four years (1,448 days) after a 13-hour vote-o-rama early Saturday morning, suggesting a small but significant return to fiscal normalcy for a country struggling to reconcile its debt and spending habits.

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The Senate budget, written by Sen. Patty Murray (D) of Washington, is more a political document than a fiscal blueprint as it stands in sharp contrast to the House budget passed on Thursday, written by former vice presidential candidate Rep. Paul Ryan (R) of Wisconsin.

Sen. Murray's budget, passed along partisan lines with a few defecting Democrats, ends $1 trillion worth of tax breaks for the wealthy, curbs but does not end deficit spending, and would spend billions on new infrastructure to help the economy. Rep. Ryan's more austere House budget reforms federal entitlement spending, shrinks the size and scope of many federal agencies, and purports to balance the federal books in 10 years without raising taxes.

Reconciling those two competing visions into one workable budget document by April may seem Sisyphean ? and it may yet be, especially given that President Obama, too, is planning to offer his own budget ? but the lengthy up and down voting on over 70 amendments into the wee hours also gave Congress a few glimmers of common ground, including support for the Keystone XL pipeline proposal, the repeal of a medical device tax that's become an unpopular aspect of "Obamacare," and stopping the United Nations from infringing on the Second Amendment right to bear arms.

Even though most of those amendments are advisory only, they supported a sense of accomplishment that's been rare in Washington.

"If Washington wasn't so dysfunctional, today would just be another day rather than a historic day," quipped conservative talk show host Sean Hannity.

Most importantly, the lack of a federal budget at a time of rising federal debt and rollercoaster spending has played into a greater sense among many Americans of a Washington unmoored from fiscal responsibility at a time when the average American wallet is thinner than it?s been in decades.

"Passage of the competing plans does advance a more orderly process after nearly three years of crises and brinkmanship,? writes the New York Times' Jonathan Weisman.

To be sure, polarized partisanship in Washington over how to set the course of the country has made it difficult, if not impossible, for the Senate in the last few years to reach the 60 votes needed to actually make a budget actionable (as opposed to the simple 51-senator majority needed to pass a budget). Moreover, the lack of a budget doesn?t technically affect the functioning of government, given various stop-gap and patch-up laws, including the Budget Control Act, passed by Congress in the last few years.

Those measures have allowed the federal government to hobble along without a fundamental budget document in place. "Not having a budget resolution in place is a symptom of the inability to reach agreement ? not the cause of Congress not being able to accomplish things," Jim Horney of the Center on Budget and Policy Priorities told the Economist last week.

While Republicans and Democrats are still miles apart on how to resolve fundamental debt and spending issues, the depth of the budget debate in the Senate gave some lawmakers hope.

"You may not feel it at the moment, but this is one of the Senate's finest days in recent years," Republican Minority Leader Mitch McConnell said, according to Business Insider.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/syp8qvaRbfY/Senate-s-first-budget-in-four-years-A-chip-off-partisan-gridlock

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Gates Foundation puts out call to make better condoms | The Verge

The Bill & Melinda Gates Foundation wants to see the stigma surrounding condom use disappear. The foundation is offering grants to researchers with promising plans to create the "next generation condom," however its biggest issue with the contraceptive is simply that many men won't use them because of decreased sensitivity. The foundation's proposal notes, "The primary drawback from the male perspective is that condoms decrease pleasure... creating a trade-off that many men find unacceptable."

Today's condoms are cheap, and easy to distribute

The foundation's intent is to broadly improve safety against sexually transmitted infections by quelling social stigmas around condom use, but the proposal's guidelines don't take into account the potential for the new condom to be widely distributed. Current condoms are cheap to manufacture and easy to distribute, which is a major factor in making it an effective tool for preventing STIs and unwanted pregnancy around the globe. However the foundation will also consider less radical proposals that would simply make condoms easier to use and open.

The grants come from the Grand Challenges in Global Health program, an initiative launched by the Bill & Melinda Gates Foundation in 2008. Grants begin at $100,000 but can go as high as $1 million, and they will be distributed later this year. The Grand Challenges initiative is meant to improve the lives of the poor through the research it sponsors, but if increased sensitivity isn't enough to drive further condom adoption, this new proposal may not have the reach that the foundation hopes to see.

Source: http://www.theverge.com/2013/3/22/4136316/gates-foundation-condom-improvement-research-grants-grand-challenges

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Cyprus seeks 11th-hour deal to avert meltdown

By Michele Kambas and Karolina Tagaris

NICOSIA (Reuters) - Cypriot President Nicos Anastasiades was expected in Brussels on Sunday to seek an 11th-hour reprieve from financial meltdown, with a bailout from the European Union and the island's place in Europe's single currency bloc hanging in the balance.

Underlining the gravity of Cyprus' position, the EU's economic affairs chief said there were now "only hard choices left" for the latest casualty of the euro zone crisis.

Facing a Monday deadline to avert a collapse of the Cypriot banking system, talks in Nicosia to seal a bailout from the EU and International Monetary Fund broke up late on Saturday without result.

"Negotiations are at a very delicate phase," the Cypriot government said in a statement.

"The situation is very difficult and the deadlines are very tight," it said. Anastasiades was due to arrive in Brussels in mid-morning to continue the talks, it said.

The tone of the statement differed sharply from earlier expressions of cautious optimism during days of intense negotiations between Cypriot leaders and officials from the island's "troika" of international lenders, the EU, IMF and European Central Bank.

Cyprus' overgrown banking sector has been crippled by exposure to crisis-hit Greece, and the EU says the east Mediterranean island must raise 5.8 billion euros ($7.5 billion) on its own before it can receive a 10 billion euro bailout.

Without a deal on Monday, the ECB says it will cut off emergency funds to Cypriot banks, spelling certain collapse and potentially pushing the country out of the euro zone.

Conservative leader Anastasiades, barely a month in the job and wrestling with Cyprus' worst crisis since a 1974 invasion by Turkish forces split the island in two, is expected to meet heads of the EU, the European Central Bank and IMF.

Finance Ministers of the 17-nation euro zone will meet at 1700 GMT Sunday.

Scrambling to find the funds, officials said Cyprus had conceded to a one-time levy on bank deposits over 100,000 euros, a dramatic U-turn from five days ago when lawmakers angrily threw out a similar proposal as "bank robbery."

A senior Cypriot official said Nicosia had agreed with its lenders on a 20 percent levy over and above 100,000 euros at the island's largest lender, Bank of Cyprus, and four percent on deposits above the same level at other banks.

'ONLY HARD CHOICES LEFT'

Finance Minister Michael Sarris spoke of "significant progress" in morning talks, as angry demonstrators outside the finance ministry chanted "resign, resign!"

The EU's Economic Affairs Commissioner, Olli Rehn, said progress was being made, but warned of tough times ahead.

"Unfortunately, the events of recent days have led to a situation where there are no longer any optimal solutions available," he said in a statement. "Today, there are only hard choices left."

In a stunning vote on Tuesday, Cyprus's 56-seat parliament rejected a levy on depositors, big and small, and Sarris spent three fruitless days in Moscow trying to win help from Russia, whose citizens have billions of euros at stake in Cypriot banks.

Rebuffed by the Kremlin, Sarris said the levy was back "on the table".

On Friday, lawmakers voted in late-night session to nationalize pension funds and split failing lenders into good and bad banks - a measure likely to be applied to No.2 lender Cyprus Popular Bank, also known as Laiki.

Cypriot media reports suggested talks were stuck on a demand by the IMF that Bank of Cyprus absorb the good assets of competitor Popular Bank and take on its nine billion euro debt to the central bank as well.

The reports said the Cypriot government was resisting.

A Cypriot plan to tap pension funds had already been shelved, a senior Cypriot official told Reuters, under opposition from Germany, which had warned the measure might be even more painful for ordinary Cypriots than a deposit levy.

It was also far from certain that a majority of lawmakers would back a revised levy, or whether the government might even try to bypass the assembly.

Ordinary Cypriots have been outraged by the levy and stunned at the pace of the unfolding drama. They elected Anastasiades in February on a mandate to secure a bailout and save banks whose capital was wiped out by investments in Greece, the epicenter of the euro zone debt crisis.

RUN ON BANKS

But for the past week they have been besieging cash machines ever since bank doors were closed on the orders of the government to avert a massive capital flight. Anticipating a run on banks when they reopen on Tuesday, parliament has given the government powers to impose capital controls.

On Saturday, some 1,500 protesters, many of them bank workers, marched on the presidency, holding banners that read, "No to the bankruptcy of Cyprus" and "Hands of workers' welfare funds".

The levy on bank deposits represents an unprecedented step in Europe's handling of a debt crisis that has spread from Greece, to Ireland, Portugal, Spain and Italy.

Cypriot leaders had initially tried to spread the pain between big holdings and smaller depositors, fearing the damage it would inflict on the country as an offshore financial haven for wealthy foreigners, many of them Russians and Britons.

The tottering banks hold 68 billion euros in deposits, including 38 billion in accounts of more than 100,000 euros - enormous sums for an island of 1.1 million people which could never sustain such a big financial system on its own.

"Cypriot banks have for years been taking the kinds of risks that are not allowed in France," Bank of France governor Christian Noyer told the French newspaper Le Journal du Dimanche. "Nobody wants Cyprus to leave the euro," he said. "The first people to suffer would be Cypriot citizens."

(Additional reporting by Jan Strupczewski and Luke Baker in Brussels, Costas Pitas and Laura Noonan in Nicosia; Writing by Matt Robinson; Editing by Giles Elgood)

Source: http://news.yahoo.com/cyprus-seeks-11th-hour-deal-avert-financial-collapse-020917086--business.html

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Last-minute scramble for $320 million Powerball jackpot

The drawing for the Powerball jackpot, now at 320 million takes place Saturday. The jackpot is the sixth highest ever. People in 42 states and Washington, D.C., were scrambling for tickets, even with odds at about 175 million to one. NBC's Lester Holt reports.

By Becky Bratu, Staff Writer, NBC News

People in 42 states, Washington, D.C., and the U.S. Virgin Islands scrambled for Powerball tickets, even with odds at about 175 million to one.

The drawing for the Powerball jackpot, now at $320 million, takes place Saturday. The lump-sum options is? $198.3 million.

The prize is the sixth highest ever. No ticket matched the six numbers in Wednesday night's Powerball drawing, and no one has won the jackpot since early February.

Bob King in Boston told NBC affiliate WHDH his daughter is getting married next month and winning the lottery could help.

?I don?t hold out hope of winning, but you can?t win unless you play, right?? King told WHDH.


?Well there's a lot of states in it, so it's a one in a million shot, but everybody has a chance,? Frank Weber of Chicopee, Mass., told NBC affiliate WWLP.

Roanna Fightei from Hardin, Mont., said she would use the winnings to help others.

"Something positive to help -- I would most definitely use more than I needed to help others," she told NBC affiliate KULR. "It's just better to love one another, and to help everybody out there. I believe it comes back at you."

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Source: http://feeds.nbcnews.com/c/35002/f/653381/s/29ea3856/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A30C230C174330A340Elast0Eminute0Escramble0Efor0E320A0Emillion0Epowerball0Ejackpot0Dlite/story01.htm

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Friday, March 22, 2013

Insights into the immune system, from the fates of individual T cells

Thursday, March 21, 2013

By charting the differing fates of individual T cells, researchers have shown that previously unpredictable aspects of the adaptive immune response can be effectively modeled. The crucial question: What determines which of the immune system's millions of cells will mobilize to fight an acute infection and which will be held back to survive long-term, forming the basis of the immunological memory? The scientists' findings, published in the journal Science, could have implications for improved immunotherapy and vaccination strategies.

The scientists found that the immediate immune response to an infection or tumor is mounted by a relatively tiny fraction of the so-called CD8+ T cells that are capable of recognizing the associated antigen. These few rapidly expand into giant populations of short-lived T cells targeted at killing infected cells or cancer cells. Meanwhile the vast majority remain in smaller populations geared toward longevity, to help ensure that the immune system will remember the antigen when it appears again in the future.

"Up to now, it was only possible to observe groups of immune cells during the response to an infection," says Prof. Dirk Busch of the Technische Universitaet Muenchen (TUM). "We have developed technology that enables us to observe individual T cells." Together with innovative cell processing technology, the researchers brought theoretical systems biology and clinical expertise to bear on this investigation, a collaboration of TUM, the University of Heidelberg, the Helmholtz Center Munich, the German Cancer Research Center (DKFZ), and the National Center for Infection Research (DZIF).

Marking the threshold of predictability

A single T cell is theoretically capable of generating an adaptive immune response by developing into diverse and expanding populations, fighting the acute infection as well as providing lasting memory for the future. But a fundamental question ? whether an effective response is predetermined on the level of an individual T cell or emerges from the commingled fates of multiple cells ? had never been put to the test. Another unresolved question concerned the order in which populations of short-lived killer cells and long-lived memory cells develop.

To address these questions, researchers at TUM began by introducing specially marked T cells into mice and then triggering a specific immune reaction. Around seven days later, they were able to determine how many descendant cells, and what kinds, had been generated by individual T cells. Biomathematical modeling, using an approach co-developed with the group of Prof. Thomas Hoefer at Heidelberg, helped to explain what the data showed. "One can't predict which 'career paths' the descendants of an individual killer T cell will take, " says first author Veit Buchholz, a medical resident at TUM. "This is a matter of chance, like a single roll of the dice. To generate a predictable immune response, we have found that a sample of at least 50 individual cells is needed."

From analysis of many of the huge populations of short-lived killer cells and the relatively tiny populations of long-lived memory cells, the researchers were able to reconstruct the T cells' development program and predict their behavior: All of the cells proceed along the same path of development, but they don't go the same distance. That is, the few cells that generate giant populations of short-lived infection fighters have gone through the same stage as those fated to produce memory cells ? but they have left that stage behind to provide immediate protection.

Beyond the results themselves, another important outcome of this study is increased confidence in the combined power of the in vivo and in silico approaches. "The fact that the experimental results confirmed our predictions in detail has strongly supported our theory," says Prof. Hoefer, leader of the Heidelberg group.

There are several ways these findings could become important in the setting of human health, the researchers explain ? in improving the effectiveness of immunotherapy against cancer, for example, or in optimizing treatment for older people, who tend to have significantly fewer copies of a given type of immune cell. "The future memory cell stands at the beginning of an expansion process with two extreme forms of differentiation," Buchholz says, "and ideally there should be a balance, so that the memory pool is not depleted. So we can think about how to tweak vaccination schemes to first allow expansion and not let differentiation kick in too early."

###

Technische Universitaet Muenchen: http://www.tum.de

Thanks to Technische Universitaet Muenchen for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127386/Insights_into_the_immune_system__from_the_fates_of_individual_T_cells

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Christina Aguilera Weight Loss Photos: Yowza!

Source: http://www.thehollywoodgossip.com/2013/03/christina-aguilera-weight-loss-photos-whoa/

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Obama withdraws appeals court pick

WASHINGTON (AP) ? President Barack Obama withdrew his nomination of Caitlin Halligan to a federal appeals court Friday, handing a victory to Republicans in the Senate who twice blocked his pick for the key judicial post.

Calling the obstruction by Republicans unjustified and unacceptable, Obama said he agreed to Halligan's request to be pulled from consideration even though she would have served with distinction on the U.S. Court of Appeals for the District of Columbia Circuit.

"I am deeply disappointed that even after nearly two and a half years, a minority of senators continued to block a simple up-or-down vote on her nomination," Obama said in a statement the White House issued while he was traveling in Jordan.

Senate Republicans blocked Halligan's confirmation for a second time in early March, arguing that Halligan is too liberal and citing her work on lawsuits against gun manufacturers and on behalf of illegal immigrants. The National Rifle Association also staunchly opposed her confirmation.

The D.C. appeals court and its makeup are of critical importance to the president, with oversight of many of the actions his administration takes. The court handles challenges to most federal rulemaking and oversees federal agencies based in Washington. Obama noted it's also often considered the second-highest court in the U.S.

It's also something of a pipeline to the Supreme Court. Four of the nine Supreme Court justices served on the D.C. Circuit before being confirmed to the higher court. Halligan herself was nominated to fill the position that John Roberts vacated when he became chief justice.

There are four vacancies on the court, with judges nominated by Republican presidents holding a 4-3 majority.

Halligan's nomination has been a flash point for Obama and Republicans since 2010, when Obama first tapped her to fill the vacancy on the bench. Republicans stalled, then used a procedural maneuver to prevent a vote on her confirmation. Obama re-nominated her at the start of 2013, but her confirmation again fell victim to GOP opposition in early March. Although a majority of senators, 51, supported Halligan's nomination, Democrats needed 60 votes in the 100-member Senate to get it past Republican objections.

Sen. Patrick Leahy, a Vermont Democrat who chairs the Senate Judiciary Committee, said Halligan is among the most qualified nominees he's ever seen a president nominate and that she would certainly have been confirmed had Republicans permitted a regular vote, where only a simple majority would be required.

"It is a shame that narrow, special interests hold such influence," he said.

In a letter Friday to Obama, Halligan said it had been a "tremendous honor" to be nominated, but she made no reference to the clash with Republicans that stymied her confirmation.

"After much reflection, I believe that the time has come for me to respectfully to withdraw my pending nomination from further consideration," wrote Halligan, general counsel for the New York County District Attorney's Office.

The skirmish over Halligan's nomination has also become entangled in a larger partisan fight over Republican efforts to hinder Obama's agenda and the use of Senate procedures to prevent the president from getting his judicial picks.

"Nominations to this court are beginning to be treated like Supreme Court nominees, with very close scrutiny," said Carl Tobias, who teaches law at the University of Richmond. "Senators could be emboldened to filibuster more appeals court nominees ? especially for the D.C. Circuit."

Democrats have accused the GOP of foiling Halligan's nomination as part of a plot to maintain a conservative majority on the key appellate court. Republicans have insisted that's not true, arguing that they objected specifically to Halligan, not Democratic nominees in general.

Republican leader Mitch McConnell called Halligan's former work as solicitor general for the state of New York "a textbook example of judicial activism." In one case he cited, Halligan filed a brief to the Supreme Court arguing that the National Labor Relations Board should have the legal authority to grant back pay to illegal aliens. In another, Halligan argued that gun manufacturers contributed to a public nuisance of illegal handguns in the state.

The White House said it has 18 judicial nominees awaiting confirmation. Among them is U.S. Magistrate Judge Patty Shwartz, who has been waiting more than a year for her confirmation to the U.S. Court of Appeals for the Third Circuit, based in Philadelphia.

Obama's judicial nominees ? not counting the Supreme Court ? have waited an average of 117 days for final confirmation after being approved in committee, the White House said. That's compared to 34 days for President George W. Bush and 16 days for President Bill Clinton at the equivalent point in their presidencies.

The White House has not said whom Obama will nominate in place of Halligan, nor what the timeline will be for making that decision.

___

Reach Josh Lederman on Twitter at http://twitter.com/joshledermanAP

Source: http://news.yahoo.com/obama-withdraws-appeals-court-pick-201927669--politics.html

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