Friday, April 5, 2013

Phones4U taking BlackBerry Q10 pre-orders, giving away PlayBooks to first 300 customers (update)

Phones4U taking BlackBerry Q10 preorders, giving away PlayBooks to first 300 customers

Know what's better than a shiny new BlackBerry Q10? A BlackBerry Q10 with a 64GB PlayBook thrown in for free, and Phones4U is the place to get it. To be clear, the UK retailer has begun taking pre-orders for the BB10 handset with a hardware keyboard today, and the first 300 folks to pledge their money will get one of BlackBerry's 7-inch slates for free along with it. As for the Q10's cost, it's £36 a month on contract or £549.95 SIM-free, with the black model expected to arrive by the end of April and the alabaster version coming in the weeks after.

Update: Should you miss out on the Phones4U deal (or just don't want a PlayBook), you can head on over to the Carphone Warehouse to place your pre-order and get a free Bluetooth speaker to pair with your Q10 instead.

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Source: Phones4U, Carphone Warehouse

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/f5DH11h-XE8/

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Zuckerberg: Home is the 'next version of Facebook,' not heading to iOS anytime soon

Zuckerberg Home is the 'next version of Facebook', not heading to iOS anytime soon

Like what you've seen so far of Home, Facebook's newly announced UI for Android devices? Well, get used to it because, according to Founder and CEO Mark Zuckerberg, it's the "next version of Facebook." The people-centric integration, shown off today on the AT&T-exclusive HTC First, makes your individual user profile the "hub" and relies heavily upon a card-like interface for swipe notifications that can be easily read and dismissed. That Facebook would look to Home, a seemingly mobile-native implementation of the social network, as the framework for its platform going forward is unsurprising -- changes recently made to News Feed were done specifically to adapt it to the smartphone space. Whether or not that means you'll see this new interface take over your desktop anytime soon remains to be seen. But take this as a sure sign that Facebook, oft criticized for lagging behind in mobile, is in major course correction mode.

As for when Home will make the transition to iOS, Zuckerberg seemed less optimistic, telling reporters that Android's openness and lack of direct oversight from Google was the major contributing factor to its unveiling today. A version of Home for iOS would require a "partnership" with Apple, which maintains strict control over its "closed" ecosystem; a pairing that would implicitly see Facebook ceding some control to Cupertino. Frame it in that manner and it's easy to see why Home's First debut is a Google-based affair and may continue to be for the foreseeable future. It does seem likely, however, that Microsoft's Windows Phone platform could play host to Home before even iOS, as Zuckerberg's referred to the live-tile OS as falling "somewhere in between" due to the licenses involved.

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Source: Facebook

Source: http://www.engadget.com/2013/04/04/zuckerberg-home-is-the-next-version-of-facebook/

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Californians support coal despite LA plan to ban it

Californian support for clean coal power?is in stark contrast to Los Angeles Mayor Antonio Villaraigosa's plan to remove coal from the city's electricity mix by the year 2025, Tracey writes.

By Evan Tracey,?American Coalition for Clean Coal Electricity (ACCCE) / April 4, 2013

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The Los Angeles, Calif., downtown skyline is pictured. The mayor of Los Angeles has announced that the city will become the only city in America that won?t get any electricity from coal by the year 2025.

Mario Anzuoni/Reuters/File

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Clean coal technology enjoys majority support among California voters. It is especially interesting that this support is broad-based, encompassing majorities of Republican, Democratic and voters declining to state a party affiliation. Given that the most important issues to California voters are ?jobs and the economy?, voter sentiment that the state?s energy policies have made it less competitive should be a red flag to Sacramento legislators.

Skip to next paragraph Evan Tracey

Senior Vice President for Communications, American Coalition for Clean Coal Electricity (ACCCE)

Mr. Tracey oversees the strategy on how to communicate the importance of electricity from coal and the value of investments in clean coal technology. He has two decades of political, legislative and issue research experience and has provided strategic media analysis for a number of trade associations, foundations, Fortune 500 companies, political party committees, the national press, academic institutions, as well as hundreds of national, statewide and local political campaigns.

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In a recent survey of California voters, nearly 57% answered yes when they were asked ?Do you support or oppose developing new clean coal power plants in California??

When asked the question, ?Do you think that California?s energy policies have made the state more or less competitive??, more than 43% answered yes. And particularly telling is the fact that nearly?one-quarter of California voters (24.7%) feel that the state?s energy policies have made the state far less competitive.

These numbers are in stark contrast to comments recently made by Los Angeles Mayor Antonio Villaraigosa when he announced that the city will become the only city in America that won?t get any electricity from coal by the year 2025.?

Army employee shot, killed at Fort Knox in Ky.

This Aug. 18, 2010 image provided by the U.S. Army shows the Chaffee Gate entrance to Fort Knox. An Army civilian employee was shot and killed in a parking lot at Kentucky's Fort Knox on Wednesday, and investigators were seeking to question a man in connection with the shooting, authorities said. Army officials said in a news release late Wednesday April 3, 2013 that the victim was an employee of the U.S. Army Human Resources Command, which handles personnel actions for soldiers. The shooting occurred in a lot outside the command. The victim was transported to the Ireland Army Community Hospital where he was pronounced dead. (AP Photo/US Army)

This Aug. 18, 2010 image provided by the U.S. Army shows the Chaffee Gate entrance to Fort Knox. An Army civilian employee was shot and killed in a parking lot at Kentucky's Fort Knox on Wednesday, and investigators were seeking to question a man in connection with the shooting, authorities said. Army officials said in a news release late Wednesday April 3, 2013 that the victim was an employee of the U.S. Army Human Resources Command, which handles personnel actions for soldiers. The shooting occurred in a lot outside the command. The victim was transported to the Ireland Army Community Hospital where he was pronounced dead. (AP Photo/US Army)

(AP) ? An Army civilian employee was shot and killed in a parking lot at Kentucky's Fort Knox, and investigators were seeking to question a man in connection with the shooting, authorities said.

Army officials said in a news release late Wednesday that the victim was an employee of the U.S. Army Human Resources Command, which handles personnel actions for soldiers. The shooting occurred in a lot outside the command. The victim was transported to the Ireland Army Community Hospital where he was pronounced dead.

"Special Agents from the U.S. Army Criminal Investigation Command are investigating a personal incident and not a random act of violence," said Chris Grey, spokesman for the independent Army investigative agency.

The identity of the victim was being withheld pending notification of family.

Police were seeking to speak with a person of interest in the case. The news release identified him as a 5-foot, 9-inch black man who is American and is believed to be using a black Yamaha motorcycle for transportation.

Fort Knox police received a 911 call about the shooting at about 5:40 pm., the news release said.

As a security measure, the post's gates were locked down at about 5:50 p.m. About an hour later, the main gate was fully reopened, but due to enhanced security measures, those coming and going were advised to expect delays.

Fort Knox spokesman Kyle Hodges said late Wednesday that the post remained on a heightened security alert, but said officials don't believe the person of interest was still on post.

He said he could not comment on whether the victim was targeted, or whether the shooting may have been related to his work. He also couldn't say what type of weapon was used.

The FBI dispatched two agents to Fort Knox and is assisting in the investigation, said Mary Trotman, a spokeswoman for the FBI in Louisville.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-04-04-Fort%20Knox%20Shooting/id-c49c8226a9814be49359b67c4b8c63dc

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Potential therapy for human prion disease

Apr. 3, 2013 ? Human diseases caused by misfolded proteins known as prions are some of most rare yet terrifying on the planet -- incurable with disturbing symptoms that include dementia, personality shifts, hallucinations and coordination problems. The most well-known of these is Creutzfeldt-Jakob disease, which can be described as the naturally occurring human equivalent of mad cow disease.

Now, scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time identified a pair of drugs already approved for human use that show anti-prion activity and, for one of them, great promise in treating these universally fatal disorders.

The study, led by TSRI Professor Corinne Lasm?zas and performed in collaboration with TSRI Professor Emeritus Charles Weissmann and Director of Lead Identification Peter Hodder, was published this week online ahead of print by the journal Proceedings of the National Academy of Sciences.

The new study used an innovative high-throughput screening technique to uncover compounds that decrease the amount of the normal form of the prion protein (PrP, which becomes distorted by the disease) at the cell surface. The scientists found two compounds that reduced PrP on cell surfaces by approximately 70 percent in the screening and follow up tests.

The two compounds are already marketed as the drugs tacrolimus and astemizole. Tacrolimus is an immune suppressant widely used in organ transplantation. Tacrolimus could prove problematic as an anti-prion drug, however, because of issues including possible neurotoxicity.

However, astemizole is an antihistamine that has potential for use as an anti-prion drug. While withdrawn voluntarily from the U.S. over-the-counter market in 1999 because of rare cardiac arrhythmias when used in high doses, it has been available in generic form in more than 30 countries and has a well-established safety profile. Astemizole not only crosses the blood-brain barrier, but works effectively at a relatively low concentration.

Lasm?zas noted that astemizole appears to stimulate autophagy, the process by which cells eliminate unwanted components. "Autophagy is involved in several protein misfolding neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's diseases," she said. "So future studies on the mode of action of astemizole may uncover potentially new therapeutic targets for prion diseases and similar disorders."

The study noted that eliminating cell surface PrP expression could also be a potentially new approach to treat Alzheimer's disease, which is characterized by the build-up of amyloid ? plaque in the brain. PrP is a cell surface receptor for A? peptides and helps mediate a number of critical deleterious processes in animal models of the disease.

The first author of the study, "Unique Drug Screening Approach for Prion Diseases Identifies Tacrolimus and Astemizole as Antiprion Agents," is Yervand Eduard Karapetyan of The Scripps Research Institute. Other authors include Gian Franco Sferrazza, Minghai Zhou, Gregory Ottenberg, Timothy Spicer, Peter Chase, Mohammad Fallahi, Peter Hodder and Charles Weissmann of The Scripps Research Institute.

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Journal Reference:

  1. Y. E. Karapetyan, G. F. Sferrazza, M. Zhou, G. Ottenberg, T. Spicer, P. Chase, M. Fallahi, P. Hodder, C. Weissmann, C. I. Lasmezas. Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1303510110

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/D8wf0tOnTHw/130403154305.htm

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Thursday, April 4, 2013

Newspaper publishes photo of Pistorius in blades

In this photo taken March 24 2013, shows Olympian athlete Oscar Pistorius running on the track at the University of Pretoria South Africa. The photo was taken by a pupil from the Voortrekker High School in Pietermaritzburg while on a hockey tour in Pretoria. A South African newspaper published the grainy cellphone image of Pistorius at a running track in his carbon fiber blades Thursday as the Olympian?s agent said his return to training was now imminent, but denied he was already in training. (AP Photo/Lisa Smith)

In this photo taken March 24 2013, shows Olympian athlete Oscar Pistorius running on the track at the University of Pretoria South Africa. The photo was taken by a pupil from the Voortrekker High School in Pietermaritzburg while on a hockey tour in Pretoria. A South African newspaper published the grainy cellphone image of Pistorius at a running track in his carbon fiber blades Thursday as the Olympian?s agent said his return to training was now imminent, but denied he was already in training. (AP Photo/Lisa Smith)

FILE - In this Sept. 5, 2012 file photo, South Africa's Oscar Pistorius competes during Men's 100m T44 round 1 at the 2012 Paralympics in London. A judge in South Africa says Pistorius, who is charged with murdering his girlfriend, can leave South Africa to compete in international competition, with conditions. (AP Photo/Emilio Morenatti, File)

FILE - In this Feb. 19, 2013 file photo, olympian Oscar Pistorius stands following his bail hearing in Pretoria, South Africa. A judge in South Africa says Pistorius, who is charged with murdering his girlfriend, can leave South Africa to compete in international competition, with conditions. (AP Photo/File)

(AP) ? A South African newspaper published a grainy cellphone photograph of Oscar Pistorius at a running track in his carbon fiber blades Thursday as the Olympian's agent said his return to training was now imminent ? but denied he was already in training.

The Afrikaans-language Beeld newspaper had the image of what it said was Pistorius, who was charged with murder for the Valentine's Day shooting death of girlfriend Reeva Steenkamp, on the front page of its Thursday edition.

In the photograph ? taken by a high school student from a bus passing by the track ? the double amputee is seen from some distance wearing his blades and dark lycra running clothes and is walking on a track with his hands on his hips.

The photo was taken on March 24 by teenager Lisa Smith, her field hockey coach said, when their team was visiting the University of Pretoria where Pistorius' regular practice facility is.

The Associated Press reported on Wednesday that Pistorius had been at the track in the South African capital city on the day of the photograph.

It was the first time Pistorius had put his blades on since he shot dead Steenkamp in his home in the early hours of Feb. 14, his agent, Peet van Zyl, told the AP later on Thursday.

Pistorius was only "having a jog around the track," the agent said, as the newspaper claimed sources had told it the Olympic 400-meter runner and Paralympic champion had begun full training at the university on March 21. Van Zyl disputed that and said neither he nor Ampie Louw, Pistorius' coach and the man who controls his training sessions, were present at the track on the day the photograph was taken.

Field hockey coach and school sports director Charmaine Koekemoer said she was driving the bus past the track at around 10.15 a.m. on the Sunday morning when members of her Hoerskool Voortrekker girls hockey team started shouting "There's Oscar, there's Oscar!" from the back.

Student Smith then took the photo on her BlackBerry, Koekemoer said. It shows Pistorius in the distance with the bars of a metal fence in the foreground. He is the only person in the shot.

"The kids were very excited," Koekemoer told the AP. "That was the excitement, seeing a world icon in real life. It was nothing to do with his case.

"We didn't see him running around the track. He was just walking to the 100 meter end line down the final stretch. It looked like he was going to take his blades off."

The single photo, a grainy image taken through the black fence and showing Pistorius walking on the far side of the track, was accompanied by a front-page story in Beeld under the headlines "Oscar is back on the track" and "In training with other athletes."

Pistorius' management team was expecting the photo to be published, Van Zyl said, after Pistorius had told them he had visited his track with some Australian athletes on the day a little under two weeks ago. Koekemoer ? who was visiting with her students from the eastern city of Pietermaritzburg ? said there were other athletes around Pistorius when they saw him.

Neither Pistorius' coach nor his agent knew about the track visit until afterward, Van Zyl said.

But while Pistorius wasn't yet in a training routine, the agent said, his return could be any day now. The image of the world's most famous disabled athlete back on his unmistakable running blades was likely now to become more and more common again.

"He might get up this morning and call (coach) Ampie (Louw) and say he wants to be at the track at one o'clock," Van Zyl said. Van Zyl also said Pistorius' desire to start training again did not show disrespect to the family of Steenkamp.

Pistorius denies murder in the Valentine's Day killing of model Steenkamp, saying he mistook her for a nighttime intruder in his home. His next scheduled court appearance is June 4, when prosecutors say they intend to serve indictments.

___

Follow Gerald Imray at www.twitter.com/GeraldImrayAP

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-04-04-OLY-Pistorius-Shooting/id-8ce9bd85cdbc4d788ec4aaf9600e315c

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Wednesday, April 3, 2013

Hubble sees J 900 masquerading as a double star

Apr. 2, 2013 ? A new image from the Hubble Space Telescope shows Jonckheere 900 or J 900, a planetary nebula -- glowing shells of ionized gas pushed out by a dying star. Discovered in the early 1900s by astronomer Robert Jonckheere, the dusty nebula is small but fairly bright, with a relatively evenly spread central region surrounded by soft wispy edges.

Despite the clarity of this Hubble image, the two objects in the picture above can be confusing for observers. J 900's nearby companion, a faint star in the constellation of Gemini, often causes problems for observers because it is so close to the nebula -- when observation conditions are bad, this star seems to merge into J 900, giving it an elongated appearance. Hubble's position above the Earth's atmosphere means that this is not an issue for the space telescope.

Astronomers have also mistakenly reported observations of a double star in place of these two objects, as the planetary nebula is quite small and compact.

J 900's central star is only just visible in this image, and is very faint -- fainter than the nebula's neighbor. The nebula appears to display a bipolar structure, where there are two distinct lobes of material emanating from its center, enclosed by a bright oval disk.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/kMnYyBDbXrY/130402101919.htm

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