'G.I. Joe' earns $40.5M at weekend box office

LOS ANGELES (AP) ? "G.I. Joe: Retaliation" conquered the weekend box office.

The shoot-'em-up sequel starring Dwayne "The Rock" Johnson, Bruce Willis and Channing Tatum as the military action figures brought to life earned $40.5 million over the weekend.

The top 20 movies at U.S. and Canadian theaters Friday through Sunday, followed by distribution studio, gross, number of theater locations, average receipts per location, total gross and number of weeks in release, as compiled Monday by Hollywood.com are:

1. "G.I. Joe: Retaliation," Paramount, $40,501,814, 3,719 locations, $10,891 average, $51,008,689, one week.

2. "The Croods," Fox/DreamWorks Animation, $26,705,868, 4,065 locations, $6,570 average, $88,887,945, two weeks.

3. "Tyler Perry's Temptation," Lionsgate, $21,641,679, 2,047 locations, $10,572 average, $21,641,679, one week.

4. "Olympus Has Fallen," FilmDistrict, $14,147,416, 3,106 locations, $4,555 average, $54,890,085, two weeks.

5. "Oz the Great and Powerful," Disney, $11,702,316, 3,324 locations, $3,521 average, $198,374,716, four weeks.

6. "The Host," Open Road Films, $10,600,112, 3,202 locations, $3,310 average, $10,600,112, one week.

7. "The Call," Sony, $4,925,675, 2,439 locations, $2,020 average, $39,605,891, three weeks.

8. "Admission," Focus Features, $3,235,263, 2,161 locations, $1,497 average, $11,744,141, two weeks.

9. "Spring Breakers," A24, $2,774,145, 1,379 locations, $2,012 average, $10,074,434, three weeks.

10. "The Incredible Burt Wonderstone," Warner Bros., $1,343,025, 1,575 locations, $853 average, $20,629,646, three weeks.

11. "Identity Thief," Universal, $1,098,215, 1,082 locations, $1,015 average, $129,916,105, eight weeks.

12. "Jack the Giant Slayer," Warner Bros., $1,019,062, 1,080 locations, $944 average, $61,399,384, five weeks.

13. "Silver Linings Playbook," Weinstein Co., $900,927, 752 locations, $1,198 average, $128,712,563, 20 weeks.

14. "Snitch," Lionsgate, $444,457, 746 locations, $596 average, $41,353,859, six weeks.

15. "Life of Pi," Fox, $427,260, 340 locations, $1,257 average, $123,321,125, 19 weeks.

16. "Safe Haven," Relativity Media, $387,754, 550 locations, $705 average, $69,811,436, seven weeks.

17. "Quartet," Weinstein Co., $382,271, 302 locations, $1,266 average, $16,599,664, 12 weeks.

18. "21 and Over," Relativity Media, $302,277, 344 locations, $879 average, $24,952,089, five weeks.

19. "The Place Beyond the Pines," Focus, $279,457, 4 locations, $69,864 average, $279,457, one week.

20. "Escape From Planet Earth," Weinstein Co., $235,117, 977 locations, $241 average, $53,927,096, seven weeks.

___

Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.

Source: http://news.yahoo.com/g-joe-earns-40-5m-weekend-box-office-223027030.html

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The Walking Dead Season 4: Who Will Return?

Source: http://www.thehollywoodgossip.com/2013/04/the-walking-dead-season-4-who-will-return/

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Understanding statin discontinuation

Public release date: 1-Apr-2013
[ | E-mail | Share ]

Contact: Jessica Maki
jmaki3@partners.org
617-534-1603
Brigham and Women's Hospital

Brigham and Women's Hospital study examines the role adverse reactions play in statin discontinuation

Boston, MA-- Despite their well-documented benefits, statins, drugs used to lower cholesterol, are commonly discontinued in routine care. Statin discontinuation has been linked to increased risk for cardiovascular events and death in patients with coronary artery disease; nevertheless, the reasons for discontinuation are only starting to be explored. In a new study from Brigham and Women's Hospital (BWH), researchers examined the role adverse reactions play in statin discontinuation and found that more than 90 percent of the patients who stopped taking a statin due to an adverse reaction, were able to tolerate it when they tried again. This study is published in the April 2, 2013 issue of the Annals of Internal Medicine.

"We were particularly interested in the role adverse reactions play in statin discontinuation," explained Alexander Turchin, MD, MS, a physician and researcher in the Division of Endocrinology at BWH and the senior author of the paper. "In my own clinical experience, I have found that many patients report adverse reactions to statins, such as muscle pain, and then stop taking them. At the same time, we often find that patients who had previously stopped taking a statin because of these adverse reactions, are ultimately able to tolerate them again the second time around."

The researchers examined clinical data from over 107,835 patients between 2000-2008, who were prescribed a statin. They used validated computational text analysis software in an electronic medical record (EMR) system to analyze statin discontinuation and identified patients who had statin-related events (possible side effects to statins), whether people stopped taking their statins after these events, whether they later restarted a statin, and what happened if they did.

The researchers found that approximately one fifth of people had a symptom or other event that may have been related to the drug, and more than half of these people stopped taking their statin, at least temporarily. More than half of the people who stopped because of an event started taking a statin again (although not necessarily the same one), and more than 90 percent of them continued taking the statin after restarting.

"We interpret these results as a glass half-full, meaning that there are potentially millions of patients who could take statins again, and ultimately reduce their risk of heart disease," explained Turchin. This study provides important take home messages for both patients and physicians. For patients, it's important to understand that just because you may have had an adverse reaction to a statin, that does not necessarily mean you should stop taking them altogether. For physicians, it's important to suggest to the patient that many times these drugs can be tolerated, and it may be time to try another statin or perhaps a lower dose

Researchers suggest that it is also important to conduct a clinical trial to determine whether rechallenging patients after statin-related events improves outcomes.

###

This research was supported by the National Library of Medicine, Diabetes Action Research and Education Foundation, and Chinese National Key Program of Clinical Science.

Brigham and Women's Hospital (BWH) is a 793-bed nonprofit teaching affiliate of Harvard Medical School and a founding member of Partners HealthCare. BWH has more than 3.5 million annual patient visits, is the largest birthing center in New England and employs more than 15,000 people. The Brigham's medical preeminence dates back to 1832, and today that rich history in clinical care is coupled with its national leadership in patient care, quality improvement and patient safety initiatives, and its dedication to research, innovation, community engagement and educating and training the next generation of health care professionals. Through investigation and discovery conducted at its Biomedical Research Institute (BRI), BWH is an international leader in basic, clinical and translational research on human diseases, involving nearly 1,000 physician-investigators and renowned biomedical scientists and faculty supported by nearly $625 million in funding. BWH continually pushes the boundaries of medicine, including building on its legacy in organ transplantation by performing the first face transplants in the U.S. in 2011. BWH is also home to major landmark epidemiologic population studies, including the Nurses' and Physicians' Health Studies, OurGenes and the Women's Health Initiative. For more information and resources, please visit BWH's online newsroom.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 1-Apr-2013
[ | E-mail | Share ]

Contact: Jessica Maki
jmaki3@partners.org
617-534-1603
Brigham and Women's Hospital

Brigham and Women's Hospital study examines the role adverse reactions play in statin discontinuation

Boston, MA-- Despite their well-documented benefits, statins, drugs used to lower cholesterol, are commonly discontinued in routine care. Statin discontinuation has been linked to increased risk for cardiovascular events and death in patients with coronary artery disease; nevertheless, the reasons for discontinuation are only starting to be explored. In a new study from Brigham and Women's Hospital (BWH), researchers examined the role adverse reactions play in statin discontinuation and found that more than 90 percent of the patients who stopped taking a statin due to an adverse reaction, were able to tolerate it when they tried again. This study is published in the April 2, 2013 issue of the Annals of Internal Medicine.

"We were particularly interested in the role adverse reactions play in statin discontinuation," explained Alexander Turchin, MD, MS, a physician and researcher in the Division of Endocrinology at BWH and the senior author of the paper. "In my own clinical experience, I have found that many patients report adverse reactions to statins, such as muscle pain, and then stop taking them. At the same time, we often find that patients who had previously stopped taking a statin because of these adverse reactions, are ultimately able to tolerate them again the second time around."

The researchers examined clinical data from over 107,835 patients between 2000-2008, who were prescribed a statin. They used validated computational text analysis software in an electronic medical record (EMR) system to analyze statin discontinuation and identified patients who had statin-related events (possible side effects to statins), whether people stopped taking their statins after these events, whether they later restarted a statin, and what happened if they did.

The researchers found that approximately one fifth of people had a symptom or other event that may have been related to the drug, and more than half of these people stopped taking their statin, at least temporarily. More than half of the people who stopped because of an event started taking a statin again (although not necessarily the same one), and more than 90 percent of them continued taking the statin after restarting.

"We interpret these results as a glass half-full, meaning that there are potentially millions of patients who could take statins again, and ultimately reduce their risk of heart disease," explained Turchin. This study provides important take home messages for both patients and physicians. For patients, it's important to understand that just because you may have had an adverse reaction to a statin, that does not necessarily mean you should stop taking them altogether. For physicians, it's important to suggest to the patient that many times these drugs can be tolerated, and it may be time to try another statin or perhaps a lower dose

Researchers suggest that it is also important to conduct a clinical trial to determine whether rechallenging patients after statin-related events improves outcomes.

###

This research was supported by the National Library of Medicine, Diabetes Action Research and Education Foundation, and Chinese National Key Program of Clinical Science.

Brigham and Women's Hospital (BWH) is a 793-bed nonprofit teaching affiliate of Harvard Medical School and a founding member of Partners HealthCare. BWH has more than 3.5 million annual patient visits, is the largest birthing center in New England and employs more than 15,000 people. The Brigham's medical preeminence dates back to 1832, and today that rich history in clinical care is coupled with its national leadership in patient care, quality improvement and patient safety initiatives, and its dedication to research, innovation, community engagement and educating and training the next generation of health care professionals. Through investigation and discovery conducted at its Biomedical Research Institute (BRI), BWH is an international leader in basic, clinical and translational research on human diseases, involving nearly 1,000 physician-investigators and renowned biomedical scientists and faculty supported by nearly $625 million in funding. BWH continually pushes the boundaries of medicine, including building on its legacy in organ transplantation by performing the first face transplants in the U.S. in 2011. BWH is also home to major landmark epidemiologic population studies, including the Nurses' and Physicians' Health Studies, OurGenes and the Women's Health Initiative. For more information and resources, please visit BWH's online newsroom.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-04/bawh-usd032713.php

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Study reveals how diabetes drug delays ageing in worms - Health.am

? Drug News ? Mar 31, 2013

A widely prescribed type 2 diabetes drug slows down the ageing process by mimicking the effects of dieting, according to a study published today using worms to investigate how the drug works.

Following a calorie-restricted diet has been shown to improve health in later life and extend lifespan in a number of animals, ranging from the simple worm to rhesus monkeys. The type 2 diabetes drug metformin has been found to have similar effects in animals but until now it was not clear exactly how the drug delays the ageing process.

Researchers supported by the Wellcome Trust and Medical Research Council looked at the effects of metformin on C. elegans worms that were grown in the presence of E. coli bacteria, a relationship similar to that which humans have with the ?healthy? bacteria in our gut. They found that the worms treated with metformin lived longer only when the E. coli strain they were cultured with was sensitive to the drug.

Dr Filipe Cabreiro from the Institute of Healthy Ageing at UCL, who led the research, explains: ?Overall, treatment with metformin adds up to 6 days of life for the worm which is equivalent to around a third of its normal lifespan. It seems to work by altering metabolism in the bacteria that live in the worm, which in turn limits the nutrients that are available to the worm host and has a similar effect to restricting the diet.?

Bacteria living in the gut have an important role in helping the host organism to digest and extract nutrition from food. Defects in gut bacteria have been linked to metabolic diseases such as obesity, diabetes, inflammatory bowel disease and cancer. It has also been suggested that gut bacteria may have an impact on the ageing process, but this is the first study to suggest a mechanism for how this works.

The team used strains of E. coli with defects in genes that are linked to metabolism and tweaked the levels of nutrients available to tease out which metabolic pathways might be affected by the drug. They found that treatment with metformin disrupted the bacteria?s ability to metabolise folate, a type of B-vitamin, and methionine, one of the building blocks of proteins. This limits the nutrients that are available to the worm and mimics the effects of dietary restriction to enable the worms to live longer.

However, when they added an excess of sugar to the diet, the team found that the life-extending effects of metformin were cancelled out. As the drug is used as a treatment for diabetes caused by elevated glucose levels in the blood, this finding is particular relevant for understanding how the drug works in people.

Professor David Gems, who directed the study, said: ?We don?t know from this study whether metformin has any effect on human ageing. The more interesting finding is the suggestion that drugs that alter bacteria in the gut could give us a new way of treating or preventing metabolic diseases like obesity and diabetes.?

Metformin is currently one of the most widely prescribed drugs and the findings should help to inform how it is used in patients.

The study was published today, Thursday 28 March, in the journal Cell.

###

Jen Middleton
j.middleton@wellcome.ac.uk
44-207-611-7262
Wellcome Trust

Provided by ArmMed Media

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Source: http://www.health.am/ab/more/diabetes-drug-delays-ageing-in-worms/

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Churches slam British government's welfare reforms

LONDON (AP) ? Government welfare reforms that include a contentious cut dubbed the "bedroom tax" will cause upheaval for some of Britain's most vulnerable people, religious leaders and anti-poverty activists claim.

The measure, which takes effect Monday, will reduce rent subsidies to social housing tenants if they have a spare bedroom.

The government ? which prefers the term "under-occupancy penalty" ? says it is one of a series of changes that will make the country's unwieldy welfare system simpler, cheaper and fairer.

But thousands of trade unionists, advocates for the disabled and anti-poverty campaigners held protest marches against the change on Saturday, and on Sunday four churches released a joint criticism of the reforms. The Baptist Union of Great Britain, the Methodist and United Reform churches and the Church of Scotland argued that "the cuts are unjust and that the most vulnerable will pay a disproportionate price."

"Our feeling is that these benefit changes are a symptom of an understanding of people in poverty in the United Kingdom that is just wrong," Methodist spokesman Paul Morrison told the BBC. ?"It is an understanding of people that they somehow deserve their poverty, that they are somehow 'lesser', that they are not valued."

Archbishop of Canterbury Justin Welby, leader of the Anglican church, has also criticized the welfare reforms.

The British government is trying to reduce public spending by 50 billion pounds ($76 billion) by 2015 in a bid to deflate Britain's ballooning deficit and kick-start its spluttering economy. It says its welfare reforms will save 4.5 billion pounds by 2014-15.

The measures include changes to disability benefits, below-inflation increases and, eventually, the replacement of a patchwork of housing, unemployment and parental benefits with one payment called the Universal Credit.

The Department for Work and Pensions says the spare-bedroom levy ? a cut of 14 percent to households with one extra room and 25 percent for two ? will save taxpayers money and will help free up social housing for families because people with too many rooms will downsize.

"It is wrong to leave people out in the cold with effectively no roof over their heads because the taxpayer is paying for rooms which aren't in use," Conservative lawmaker Grant Shapps told Sky News.

Officials say the new rules won't apply to retirees, or to those who really need extra space, such as parents of severely disabled children.

But campaigners say the "bedroom tax" has already produced injustices. Parents whose children are not considered disabled enough by local officials have been told they must pay. So has a bereaved couple who couldn't bear to change the bedroom of their 7-year-old daughter after she died of brain cancer.

To its opponents, the "bedroom tax" is an indignity on a par with the "poll tax," a levy on every adult that sparked violent protests and helped bring down Prime Minister Margaret Thatcher in 1990. Her successor, John Major, scrapped it.

The government says its welfare reforms are modest measures that will encourage people to get off welfare and find jobs. In tough times, officials say, everyone must make sacrifices.

Opponents ask why the government can't tax mansions or second homes, rather than the poor. And they allege the cuts will force impoverished residents to move from homes and neighborhoods where they have lived for years.

Frank Field, a minister in the previous Labour administration and now a government adviser on fighting poverty, told The Guardian newspaper that "the government is introducing social and physical engineering that Stalin would have been proud of."

___

Jill Lawless can be reached at http://Twitter.com/JillLawless

Source: http://news.yahoo.com/churches-slam-british-governments-welfare-reforms-120851734.html

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Blunts And Dancing Dogs In Tutus: How The Sharing Economy Is Re-Humanizing Business

I feel oddly guilty rejecting my Uber driver’s offer of a beer and a blunt. It’s 4 am. I’m drenched, hungover, and bewildered as to why I’m in a rustic garage on the outskirts of downtown Austin, watching tattooed pedicab drivers dance with a tiny dog in a pink tutu. This was not the ride home I expected. Yet, my experience isn’t entirely unusual. After two years of experimenting with Internet services that allow everyday individuals to sell their cars, houses, and things — the so-called “sharing economy” — I’ve become accustomed to getting a face full of the sellers’ hopes, fears and quirks. Between services rendered and cash exchanged, friendships are forged, awkwardness is experienced, and memories are made. Before the Industrial Revolution uprooted us from our small-town community roots, I imagine most business transactions included a side of humanity. Modern-day business sterilize transactions of the personal element. Human resource departments have hollowed out their employees, leaving little more than a pleasantly smiling husk of a person. South By Southwest By The Sharing Economy Every March, over 25,000 technology enthusiasts cram into the moderately sized metro of downtown Austin for the annual tech pilgrimage, South By Southwest Interactive. Hotels are sold out six months in advance, and every public service is bleeding out their windows with demand. You’d have an easier time catching a cab stumbling naked and drunk down Times Square on New Years Eve than hailing a taxi during SXSW. At 4 a.m., after the final after parties had simmered down, the only shot I had at making it back to my bed before I had to wake up the next morning was Uber, the popular smartphone taxi application that had contracted with independent pedicabers during SXSW, to usher sleepy technologists to and fro downtown Austin. I did not, however, foresee the torrential downpour halfway though my trip that instantly saturated my clothes to my frigid bone. No longer able to stand the sharp icicles falling from the sky, yet still needing to finish the ride, our courtesy pedicab driver took a pit stop at Pediacab HQ to pick up his car and stow his bike. Pedicab headquarters is like the second-class deck of the Titanic, a dimly lit haven where free-spirited tattooed servicemen party their blue collars off to loud music, an abundance of cheap beer, and liberally available recreational drugs. “I got jungle juice for

Source: http://feedproxy.google.com/~r/Techcrunch/~3/3GWM3x9ODtQ/

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L.A. police ID suspect in girl's abduction case

LOS ANGELES (AP) ? Investigators are seeking a transient who has a long criminal record in the kidnapping of a 10-year-old who was snatched from her San Fernando Valley home before dawn last week and abandoned hours later in front of a hospital, police said.

Tobias Dustin Summers, 30, was identified by police Saturday as a suspect in the case but they couldn't elaborate on the motive or what led them to him. Police don't know if the girl was targeted but said they don't believe Summers had a connection to her family.

"We have no information that the family knew this individual or that the individual knew any members of the family," Los Angeles Police Deputy Chief Kirk Albanese said.

About 40 detectives have been working around the clock looking for clues since the girl was abducted from her home Wednesday. She was found hours later, wandering near a Starbucks several miles away.

The girl was barefoot, had bruises and scratches, and wasn't wearing the same clothes she had on when she vanished. She told the police two men she didn't recognize had taken her from her home.

Police initially said they were looking for two suspects, but now are focusing their efforts on locating Summers.

"This is the only person we are looking for right now," Albanese said Saturday.

Investigators have said they believe the girl was driven around the San Fernando Valley in a couple of cars and taken to at least two locations, including a storage facility, before she was released.

A passer-by who recognized her picture from media reports saw her outside the Starbucks and called police. The girl had wandered there from the hospital where she had been dropped.

Summers, who has a distinctive tattoo of a ghoulish face on his right arm, has arrests dating back to 2002, police said. Among them are robbery, grand theft auto, possession of explosives and kidnapping, authorities said.

Police said they had no details on the prior kidnapping case.

Summers was released from prison in July on a petty theft conviction as part of a California law designed to ease crowding in state prisons. He also spent six days behind bars in January on a probation violation.

Summers last checked in with his probation officer at some point earlier this month and had been complying with his release terms, police said. He is known to frequent the area where the kidnapping took place.

The Los Angeles Times reported that law enforcement sources said the girl was sexually assaulted. The Associated Press does not identify victims of sexual assault. Summers isn't a registered sex offender, police said.

Albanese said Summers had been arrested four years ago for investigation of battery that involved child annoyance. Court records show Summers was convicted of battery in September 2009 but the child annoyance charge was either dismissed or not prosecuted.

Summers has family in Southern California, according to police, and the FBI said it will obtain a warrant for unlawful flight to avoid prosecution, if the agency determines he has fled the state.

Source: http://news.yahoo.com/la-police-id-suspect-girls-abduction-case-223900956.html

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